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E3893

Sigma-Aldrich

(−)-表儿茶素没食子酸酯

≥98% (HPLC), from green tea

别名:

(-)-cis-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, (-)-cis-3,3′,4′,5,7-Pentahydroxyflavane 3-gallate, 3- O -没食子酰表儿茶精

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About This Item

经验公式（希尔记法）:
C22H18O10
CAS号:
1257-08-5
分子量:
442.37
MDL號碼:
MFCD00075936
分類程式碼代碼:
12352205
PubChem物質ID:
24894531
NACRES:
NA.21

生物源

green tea

品質等級

100

化驗

≥98% (HPLC)

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

2-8°C

SMILES 字串

Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4ccc(O)c(O)c4

InChI

1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2/t19-,21-/m1/s1

InChI 密鑰

LSHVYAFMTMFKBA-TZIWHRDSSA-N

基因資訊

human ... CYP1A2(1544)

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相关类别

一般說明

(−)-表儿茶素没食子酸酯是绿茶的主要多酚成分之一，属于儿茶素没食子酸酯类有机化合物。ECG的化学结构与绿茶中的另一种主要多酚(−)-表没食子儿茶素没食子酸酯(EGCG)相似。

應用

(−)-表儿茶素没食子酸酯已用于：
  • 通过人脑微血管内皮细胞(HBMVEC)的增殖检测，了解其抗缺血再灌注损伤的有效性
  • 作为人唾液α-淀粉酶(HAS)和α-葡萄糖苷酶(AGH)抑制检测的抑制剂
  • 可用作人结直肠细胞系HCT-116和SW-480的多酚类癌症化学预防药物
  • 作为胶原酶和弹性蛋白酶的体外抑制剂
  • 作为精子培育的添加剂，验证其抗氧化应激作用的有效性

生化／生理作用

(−)-表儿茶素没食子酸酯(ECG)是强效的自由基清除剂，因对胶原蛋白和弹性蛋白酶具有抑制作用而可用作抗老化剂。它对人结直肠细胞具有抗增殖作用，因而可用作化学预防药物。它影响细胞生存，可通过促进氧糖剥夺的人脑微血管内皮细胞的增殖，防止细胞凋亡或自噬。ECG在结构与功能上都与EGCG类似，可参与内质网应激中哺乳动物雷帕霉素靶蛋白(mTOR)-AMP激活蛋白激酶(AMPK)通路的平衡。它在这种情况下可抵抗氧剥夺造成的细胞损伤，从而防止细胞死亡。ECG可参与防止氧化应激。它可有效抑制多种疾病状态下的分泌性鞘磷脂酶作用，并在辅助生殖技术(ART)中为人类精子提供保护。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
WXBD6835V
WXBD3508V
WXBD0502V
WXBD0103V
WXBC6927V

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Lee Wah Koh et al.
Journal of agricultural and food chemistry, 58(1), 148-154 (2010-01-07)
Current work investigated the ability of different tea (green, oolong and black teas) in inhibiting human salivary alpha-amylase (HSA) and mammalian alpha-glucosidase (AGH). The inhibitory profiles were correlated to their major polyphenol content (theaflavins and catechins). The fully fermented black
Bing Fu et al.
Oxidative medicine and cellular longevity, 2019, 7824684-7824684 (2019-04-10)
Green tea is one of the most beverages with antioxidants and nutrients. As one of the major components of green tea, (-)-epicatechin gallate (ECG) was evaluated for its antioxidative properties in the present study. Cell proliferation assay, tube formation, cell
Wanda C Reygaert
BioMed research international, 2018, 9105261-9105261 (2018-08-15)
Green tea is one of the most popular drinks consumed worldwide. Produced mainly in Asian countries from the leaves of the Camellia sinensis plant, the potential health benefits have been widely studied. Recently, researchers have studied the ability of green
Sven Stadlbauer et al.
Chemical communications (Cambridge, England), 48(67), 8425-8427 (2012-07-14)
Concise synthesis of (-)-epicatechin and its 3-O-gallate is described, illustrating efficacy of the new strategy for catechin-class polyphenols based on assembly of lithiated fluorobenzene and epoxy alcohol followed by a pyran cyclization. 1,3,5-Trifluorobenzene serves as the A-ring equivalent for functionalization
Kusum Rathore et al.
Carcinogenesis, 33(1), 174-183 (2011-11-03)
Long-term exposure to low doses of environmental carcinogens contributes to sporadic human breast cancers. Epidemiologic and experimental studies indicate that green tea catechins (GTCs) may intervene with breast cancer development. We have been developing a chronically induced breast cell carcinogenesis
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