MABN787

Anti-Dual oxidase 2, clone Duox S-12 Antibody

clone Duox S-12, from mouse

• 别名: Dual oxidase 2, Large NOX 2, Long NOX 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, Thyroid oxidase 2, p138 thyroid oxidase
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: Duox S-12, monoclonal
• 物種活性: human
• 技術: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_054799
• UniProt登錄號: Q9NRD8
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... DUOX2(50506)

说明

一般說明

Dual oxidase 2 is an important enzyme in thyroid hormone biosynthesis and peroxide metabolism. Dual oxidase 2 generates the hydrogen peroxide needed for thyroid peroxidase and lactoperoxidase enzymes as well as processes H2O2 made during metabolic processes. Dual oxidase also plays a role in anti-microbial defense in our mucous membranes by providing the peroxidase for lactoperoxidase’s antimicrobial activities. Dual oxidase 2 is also needed for various extracellular matrix stabilizations and protein cross-linking needs such as during cuticle formation. Dual oxidase 2 is widely expressed in the developing fetus, and in the adult, it is largely expressed in the mucosal and epithelial cells and linings of the gut, lung, salivary glands and testis. Dual oxidase also plays a role in many hypersensitivity and inflammatory diseases and is upregulated in diseases such as colitis and certain cancers.

免疫原

Epitope: N-terminus

Recombinant protein corresponding to the N-terminus of human Dual oxidase 2.

應用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Dual oxidase 2 in human prostate cancer and human breast cancer tissue.
Western Blotting Analysis: A representative lot detected Dual oxidase 2 in BxPC-3 cell lysate (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).
Immunocytochemistry Analysis: A representative lot detected Dual oxidase 2 in MIA PACA-2 cell (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).
Immunohistochemistry Analysis: A representative lot detected Dual oxidase 2 MIA PACA-2 tissue (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This Anti-Dual oxidase 2, clone Duox S-12 Antibody is validated for use in Western Blotting and Immunohistochemistry and Immunocytochemistry for the detection of Dual oxidase 2.

品質

Evaluated by Western Blotting in BxPC3 treated with IL-4 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Dual oxidase 2 in 10 µg of BxPC3 treated with IL-4 cell lysate.

標靶描述

~175 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable