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生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
TAU-5, monoclonal
物種活性
human, rat
物種活性（以同源性預測）
bovine (immunogen homology)
技術
western blot: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... MAPT(4137)
mouse ... Mapt(281296)
rat ... Mapt(29477)
一般說明
Tau is a neuronal protein implicated in several neurodegenerative disorders, among which Alzheimer’s disease, Picks’s disease, and frontotemporal dementia are most widely studied. Tau interacts extensively with the cytoskeleton via its microtubule-binding domain and is involved in the assembly and stabilization of microtubules. Tau also contains proline rich domains and multiple phoshorylation sites which are targeted by a wide variety of kinases including JNK, MAPK, GSK3, PKA, PKC, and CAMKII. In disease conditions, Tau is hyperphosphorylated and insoluble and occurs mainly in the form of toxic neurofibrillary tangles that destabilizes the cytoskeleton, and disrupts axonal transport and intracellular signaling networks. Neurodegeneration resulting from accumulation of defective tau proteins is marked by a range of cognitive deficits, among other debilitating symptoms.
免疫原
Purified bovine Tau
應用
Detect Tau, a.a. 210-241, clone Tau-5 using this Anti-Tau, a.a. 210-241 Antibody, clone Tau-5 validated for use in Western Blotting.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
品質
Purified by Western Blot in rat cortex tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody recognized Tau in 10 µg of rat cortex tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody recognized Tau in 10 µg of rat cortex tissue lysate.
標靶描述
~48 kDa observed. This antibody is expected to recognize all phosphorylated and nonphosphorylated isoforms of Tau at molecular weights of ~45-68 kDa
聯結
Replaces: MABN361; 577801
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
儲存和穩定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
分析報告
Control
Rat cortex tissue lysate
Rat cortex tissue lysate
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Lucia Buccarello et al.
Oncotarget, 8(47), 83038-83051 (2017-11-16)
Recently a range of ocular manifestations such as retinal and lens amyloid-beta accumulation and retinal nerve fiber layer loss have been proposed as potential biomarkers in Alzheimer disease (AD). The TgCRND8 mouse model of AD exhibits age-dependent amyloid β (Aβ)
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