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生物源
rat
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
8H2, monoclonal
物種活性
human
技術
flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable
同型
IgG2aκ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... NLRP10(338322)
一般說明
NACHT, LRR and PYD domains-containing protein 10 (NLRP10) is also called Nucleotide-binding oligomerization domain protein 8. NLRP10 has anti-inflammatory activity and plays a role in immune response against infections from bacteria including C.albicans by contributing to proinflammatory cytokine release. NLRP10 is widely expressed with the highest levels found in heart, brain and skeletal muscle, as well as liver, colon, dermis and epidermis.
免疫原
Recombinant protein corresponding to human NLRP10.
應用
Anti-NLRP10 Antibody, clone 8H2 is a highly specific rat monoclonal antibody, that targets NLRP10 & has been tested in western blotting, Flow Cytometry & ICC.
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected NLRP10 in Flag-tagged NRLP10 transfected HeLa cells (Lautz, K., et al. (2012). Cell Microbiol. 14(10:1568-1583.).
Western Blotting Analysis: A representative lot from an independent laboratory detected NLRP10 primary epidermal fibroblasts transfected with a non-targeting control siRNA, and demonstrated a loss of signal in primary epidermal fibroblasts transfected with NLRP10-specific RNA (Lautz, K., et al. (2012). Cell Microbiol. 14(10:1568-1583.).
Flow Cytometry Analysis: 4 µg from a representative lot detected NLRP10 in 1X10E6 HeLa and Jurkat cells.
Western Blotting Analysis: A representative lot from an independent laboratory detected NLRP10 primary epidermal fibroblasts transfected with a non-targeting control siRNA, and demonstrated a loss of signal in primary epidermal fibroblasts transfected with NLRP10-specific RNA (Lautz, K., et al. (2012). Cell Microbiol. 14(10:1568-1583.).
Flow Cytometry Analysis: 4 µg from a representative lot detected NLRP10 in 1X10E6 HeLa and Jurkat cells.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
品質
Evaluated by Western Blotting in A431 cell lysate.
Western Blotting Analysis: 1 mg/mL of this antibody detected NLRP10 in 10 µg of A431 cell lysate.
Western Blotting Analysis: 1 mg/mL of this antibody detected NLRP10 in 10 µg of A431 cell lysate.
標靶描述
~72 kDa observed
外觀
Protein G Purified
Format: Purified
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
A431 cell lysate
A431 cell lysate
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Katja Lautz et al.
Cellular microbiology, 14(10), 1568-1583 (2012-06-08)
Members of the NLR family evolved as intracellular sensors for bacterial and viral infection. However, our knowledge on the implication of most of the human NLR proteins in innate immune responses still remains fragmentary. Here we characterized the role of
Seok-Joo Lee et al.
Innate immunity, 23(7), 569-577 (2017-08-03)
This study investigated the pathogenesis of periodontitis and the role of nucleotide-binding oligomerization domain-like receptor protein 10 (NLRP10). The human oral epithelial cell line HOK-16B was infected with two periodontal pathogens, Tannerella forsythia and Fusobacterium nucleatum, at various MOIs. RT-PCR
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