推荐产品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
11C1.3, monoclonal
物種活性
bovine, pig, human
製造商／商標名
Chemicon®
技術
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
unmodified
基因資訊
human ... FBN1(2200)
特異性
Bovine zonular fibrils. Reacts well with human elastin microfibrils and can be used to investigate the presence and organization of these fibrils either in Marfan patients or in fibroblasts obtained from these patients.
免疫原
Bovine zonular fibrils
應用
Anti-Fibrillin Antibody, clone 11C1.3 is an antibody against Fibrillin for use in ELISA, IF, IP, WB, IH(P).
Immunoblot: antibody reacts with 350,000 Da protein released from bovine aortic smooth muscle cells, which is identical to that of fibrillin.
Immunohistochemistry: fresh frozen tissue: 1:200-1:500. Paraffin sections reactive after microwave citrate buffer antigen retrieval.
Immunoprecipitation: 5 microliters of antibody diluted in no more than 400 microliters of concentrated supernatants from bovine smooth muscle cells. We recommend either an anti-mouse IgG bead or a rabbit anti-mouse capture antibody followed by protein A.
ELISA
Optimal dilutions must be determined by the end user.
Immunohistochemistry: fresh frozen tissue: 1:200-1:500. Paraffin sections reactive after microwave citrate buffer antigen retrieval.
Immunoprecipitation: 5 microliters of antibody diluted in no more than 400 microliters of concentrated supernatants from bovine smooth muscle cells. We recommend either an anti-mouse IgG bead or a rabbit anti-mouse capture antibody followed by protein A.
ELISA
Optimal dilutions must be determined by the end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
ECM Proteins
ECM Proteins
外觀
Format: Purified
Liquid
儲存和穩定性
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The topography of microstructured surfaces differently affects fibrillin deposition by blood and lymphatic endothelial cells in culture.
Antonella Rossi, Daniela Pasqui, Rolando Barbucci, Renato Gerli, Elisabetta Weber et al.
Tissue Engineering: Part A null
Rachel Kinsey et al.
Journal of cell science, 121(Pt 16), 2696-2704 (2008-07-26)
Newly deposited microfibrils strongly colocalise with fibronectin in primary fibroblasts. Microfibril formation is grossly inhibited by fibronectin depletion, but rescued by supplementation with exogenous cellular fibronectin. As integrin receptors are key determinants of fibronectin assembly, we investigated whether they also
ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts.
Kutz, WE; Wang, LW; Bader, HL; Majors, AK; Iwata, K; Traboulsi, EI; Sakai, LY; Keene, DR; Apte, SS
The Journal of Biological Chemistry null
Nicholas Hatzirodos et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(7), 2256-2265 (2011-03-18)
Although not often discussed, the ovaries of women with polycystic ovary syndrome (PCOS) show all the hallmarks of increased TGF-β activity, with increased amounts of fibrous tissue and collagen in the ovarian capsule or tunica albuginea and ovarian stroma. Recent
Placental extracellular matrix: gene expression, deposition by placental fibroblasts and the effect of oxygen.
C-P Chen, J D Aplin, C-P Chen, J D Aplin
Placenta null
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