FCMAB288A6

Milli-Mark^® Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor^™647, clone Apu3

clone Apu3, Milli-Mark^®, from rabbit

• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.45

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: ALEXA FLUOR^™ 647
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: Apu3, monoclonal
• 物種活性: human
• 製造商／商標名: Milli-Mark^®
• 技術: flow cytometry: suitable
• 同型: IgG
• UniProt登錄號: P0CG48
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... UBB(7314)

说明

一般說明

Polyubiquitin chains linked through the Lys48 residue of ubiquitin are most commonly associated with proteins targeted for proteosomal degradation. In contrast, polyubiquitin chains linked through the Lys63 residue of ubiquitin (Ub) are associated with nonproteolytic functions such as signal transduction. Lys63-linked polyUb chains connect components of NFκB signaling in a highly regulated manner, and genetic evidence indicates the involvement of Lys63-linked Ub chains in stress response and DNA repair. Research in yeast has suggested Lys63-linked Ub chains stimulate endocytosis.

特異性

Recognizes ubiquitin linked at Lys63. Does not recognize ubiquitin linked at Lys48 or free ubiquitin.

免疫原

Immunogen used was di-ubiquitin linked at Lys63.

應用

This Milli-Mark Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor647, clone Apu3 is validated for use in FC for the detection of Ubiquitin.

品質

Evaluated by flow cytometry using HeLa cells

標靶描述

Molecular weight varies.

外觀

Purified recombinant rabbit monoclonal IgG1 conjugated to Alexa Fluor 647 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

法律資訊

ALEXA FLUOR is a trademark of Life Technologies

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable