ABN30

Anti-Aromatase Antibody

from rabbit, purified by affinity chromatography

• 别名: Cytochrome P450 19A1, Aromatase, CYPXIX, Cytochrome P-450AROM, Estrogen synthase
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human, pig
• 物種活性（以同源性預測）: chimpanzee (based on 100% sequence homology), porcine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology)
• 技術: western blot: suitable
• NCBI登錄號: NP_000094
• UniProt登錄號: P11511
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CYP19A1(1588)

说明

一般說明

Human Aromatase is a membrane-bound enzyme that is localized on the endoplasmic reticulum. While it is found in gonads and adrenal glands where it converts androgens into estrogens in a classical endocrine manner, it is also expressed in various tissues where it regulates local estrogen levels or estrogen/androgen ratios in an intracrine manner. Human Aromatase is known to have two major forms, characterized by one amino acid difference at amino acid position 264 [arginine (264R) and cysteine (264C)]. Abnormal Aromatase hyperactivity is a known cause for Aromatase excess syndrome (AES), which is characterized by excess levels of estrogen, heterosexual precocity in adolescent males and isosexual precocity in adolescent females. On the other hand, Aromatase deficiency (AROD) in Aromatase-deficient (ArKO) mice leads to increased adiposity, an inability to synthesize estrogen, birth defects, and genital-related developmental disorders. It is also reported to play a role in a complex immune-neuro-endocrine network management system in murine cysticercosis.

特異性

Other homolgoies: Rat and Mouse (94% sequence homology).

免疫原

KLH-conjugated linear peptide corresponding to human Aromatase.

應用

Anti-Aromatase Antibody is an antibody against Aromatase for use in WB.

Research Category
Neuroscience

Research Sub Category
Neurochemistry & Neurotrophins

Western Blot Analysis: 1 µg/mL from a representative lot detected Aromatase in 10 µg of human testis.

品質

Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Aromatase in 10 µg of human placenta tissue lysate. Tween was not used in the Western Blot.

標靶描述

~58 kDa observed. UniProtKB/Swiss-Prot P11511 (CP19A_HUMAN) states a molecular weight of ~58 kDa

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human placenta tissue lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable