跳转至内容
Merck
所有图片(1)

Key Documents

AB6001

Sigma-Aldrich

Anti-MMP-9 Antibody, NT

from rabbit, purified by affinity chromatography

别名:

92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, macrophage gelatinase, matrix metallopeptidase 9, matrix metalloproteinase 9, type V collagenase

登录查看公司和协议定价


About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

canine, human

物種活性(以同源性預測)

primate (based on 100% sequence homology), pig (based on 100% sequence homology), dog (based on 100% sequence homology), rat (based on 100% sequence homology), horse (based on 100% sequence homology), monkey (based on 100% sequence homology)

技術

western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... MMP9(4318)

一般說明

All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn2+ binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases).

MMP9, also known as gelatinase B, is a secreted enzyme which degrades the interstitial collagens, types I, II, and III and is produced by normal alveolar macrophages and granulocytes.

特異性

The antibody recognizes human MMP-9. It does not cross react with MMP-1 or MMP-2.

免疫原

Epitope: N-terminus
KLH-conjugated synthetic peptide corresponding to the N-terminus of MMP-9.

應用

Anti-MMP-9 Antibody, N-terminus is an antibody against MMP-9 for use in WB.
Research Category
Cell Structure
Research Sub Category
MMPs & TIMPs

品質

Evaluated on a representative lot by Western blot using an HL-60 cell lysate supplemented with a PMA conditioned media.

Western Blot Analysis: 0.5 µg/ml of this antibody detected MMP-9 on 10 µg of HL-60 plus PMA conditioned media.

標靶描述

92kDa (pro-form) and 88kDa (active form)

聯結

Replaces: AB805

外觀

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
HL-60 plus PMA conditioned media

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品?  

试试我们的产品选型工具.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Haiying Yue et al.
Experimental and therapeutic medicine, 10(4), 1437-1444 (2015-12-02)
Radiation-induced lung injury (RILI) is a common complication associated with thoracic radiotherapy. The aim of the present study was to investigate the effects of a single 15-Gy dose of right-thoracic lung irradiation on the expression levels of matrix metalloproteinases (MMPs)
Alexander C W Smith et al.
Nature neuroscience, 17(12), 1655-1657 (2014-10-20)
Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门