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AB5403

Sigma-Aldrich

抗-NMDAR2B抗体，磷酸Tyr 1472

Chemicon®, from rabbit

别名:

Anti-DEE27, Anti-EIEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

100

抗體表格

affinity purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

rat

製造商／商標名

Chemicon®

技術

western blot: suitable

NCBI登錄號

NM_000834.2

UniProt登錄號

Q13224

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

rat ... Grin2B(24410)

特異性

NMDAR2B，磷酸Tyr1472。 该抗体在蛋白质印迹中可识别约180 kDa的蛋白。 大鼠脑蛋白质印迹中NMDAR2B蛋白的标记被磷酸肽阻断，但未被去磷酸肽阻断。 大鼠脑的蛋白质印迹中还存在另外两个较低的分子量带。

免疫原

对应于大鼠NMDAR2B磷酸Tyr1472周围氨基酸的合成肽。
表位：磷酸Tyr 1472

應用

抗NMDAR2B抗体，磷酸Tyr 1472是用于WB的针对NMDAR2B的抗体。
研究子类别
神经递质& 受体
研究类别
神经科学
蛋白质印迹：1：1,000

最佳工作稀释度必须由最终用户进行确定。

外觀

亲和纯化的免疫球蛋白。 10 mM HEPES（pH值7.5），150 mM NaCl和100 μg/mL BSA，50%甘油和0.09%叠氮化钠的液体。

儲存和穩定性

自收到之日起，在-20° C以未稀释的等分试样可保存 6 个月。应避免反复冻/融循环。 请勿储存在自动除霜冰箱中。

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 2

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Sofia Lopes et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(26), E3755-E3763 (2016-06-09)
Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyperphosphorylation and missorting into dendritic spines followed by memory
Hong-Bin Yang et al.
Journal of neurochemistry, 116(1), 93-104 (2010-11-09)
Selective inhibition of GluN2B-containing NMDA receptor (GluN2BR) in spinal dorsal horn effectively alleviates inflammatory pain, suggesting the up-regulation of GluN2BR function involved in central sensitization. Previous studies have demonstrated that the increase in GluN2BR synaptic expression serves as a key
Sehoon Won et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(32), E4736-E4744 (2016-07-28)
Phosphorylation regulates surface and synaptic expression of NMDA receptors (NMDARs). Both the tyrosine kinase Fyn and the tyrosine phosphatase striatal-enriched protein tyrosine phosphatase (STEP) are known to target the NMDA receptor subunit GluN2B on tyrosine 1472, which is a critical
Jérémy Ferrier et al.
PloS one, 8(10), e77828-e77828 (2013-11-10)
Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D-aspartate (NMDA) receptors, particularly
Dan Ren et al.
Neuroscience bulletin, 38(4), 342-358 (2021-12-16)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a

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