推荐产品
生物源
rabbit
品質等級
抗體表格
affinity purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
mouse, rat, human
製造商／商標名
Chemicon®
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... ENDOG(2021)
mouse ... Endog(13804)
rat ... Endog(362100)
特異性
Recognizes Endonuclease G (EndoG), a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. EndoG is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2).
免疫原
Synthetic peptide corresponding to amino acids 55 to 70 of human EndoG (GGPRGPGELAKYGLP).
應用
Anti-Endonuclease G Antibody is an antibody against Endonuclease G for use in WB.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Western blotting (1-2μg/mL)
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
外觀
Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
儲存和穩定性
Maintain at 2-8ºC for 12 months.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
L Y Li et al.
Nature, 412(6842), 95-99 (2001-07-14)
Nucleosomal fragmentation of DNA is a hallmark of apoptosis (programmed cell death), and results from the activation of nucleases in cells undergoing apoptosis. One such nuclease, DNA fragmentation factor (DFF, a caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD)), is capable
Shuangping Zhao et al.
Journal of neuroscience research, 88(8), 1727-1737 (2010-01-16)
We have shown that generalized seizures produce necrotic neurons with caspase-independent nuclear pyknosis and DNA fragmentation. In this study, we determined the time course of translocation of mitochondrial cytochrome c, apoptosis-inducing factor, endonuclease G, lysosomal cathepsins B and D, and
Caspase-independent pathways of hair cell death induced by kanamycin in vivo
Jiang, H, et al
Cell Death and Differentiation, 13, 20-30 (2006)
Po-Yuan Chen et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 718320-718320 (2012-08-25)
Phenethyl isothiocyanate (PEITC), an effective anticancer and chemopreventive agent, has been reported to inhibit cancer cell growth through cell-cycle arrest and induction of apoptotic events in various human cancer cells models. However, whether PEITC inhibits human oral squamous cell carcinoma
Mitochondrial endonuclease G is important for apoptosis in C. elegans.
Parrish, J, et al.
Nature, 412, 90-94 (2001)
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