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Merck
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文件

408727

Sigma-Aldrich

支化聚乙烯亚胺

average Mw ~25,000 by LS, average Mn ~10,000 by GPC, branched

别名:

氮丙啶，均聚物, PEI

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About This Item

线性分子式:
H(NHCH2CH2)nNH2
CAS号:
9002-98-6
MDL號碼:
MFCD00084427
分類程式碼代碼:
12162002
PubChem物質ID:
24865591
NACRES:
NA.23

品質等級

200

形狀

viscous liquid

分子量

average Mn ~10,000 by GPC
average Mw ~25,000 by LS

雜質

≤1% water

折射率

n20/D 1.5290

黏度

13,000-18,000(50 °C)

bp

250 °C (lit.)

密度

1.030 g/mL at 25 °C

SMILES 字串

C1CN1

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI 密鑰

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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一般說明

聚乙烯亚胺（PEI）是一种亲水性阳离子聚合物， 被广泛用作非病毒核苷酸转染试剂。支链PEI可以 通过氮丙环的阳离子开环聚合反应合成。PEI基 颗粒也可用作疫苗的助剂。由于其良好的 理化性质，它在许多领域中得到了应用，如 蛋白质的分离纯化、二氧化碳吸收、药物载体、 废水处理和生物标记。

應用

聚乙烯亚胺可用作非病毒合成聚合物载体，用于治疗性核酸的体内输送。 带负电荷的核酸和带正电荷的聚合物主链之间的相互作用导致纳米络合物的形成。这种中性络合物保护被包裹的核酸免于遭受酶的作用，并维持其稳定性直至发生细胞摄取。例如，与人血清白蛋白结合的PEI 具有良好的pDNA 转染性能和低毒性。

PEI可用于单壁纳米管 (SWNT) 的功能化修饰，以改善其溶解性和生物相容性，同时维持原始SWNT的结构完整性。共价功能化的SWNT可应用于 CO2 吸收和基因递送。

支链PEI也可用于改变吸附剂的表面性质。PEI修饰的水合氧化锆/PAN纳米纤维可用于地下水的脱氟，因为其具有高氟吸附能力和宽工作pH范围。

特點和優勢

PEI的伯胺和仲胺基团可以高效地结合 药物、核酸和其它功能基团。

支链PEI 具有更好的络合和缓冲能力。

外觀

支化聚合物

象形圖

Exclamation markEnvironment
GHS07,GHS09

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 2

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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