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Key Documents

AB10140

Sigma-Aldrich

Anti-Drebrin A/E Antibody

from rabbit, purified by affinity chromatography

别名:

Developmentally-regulated brain protein, drebrin 1, drebrin E, drebrin E2

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

rat, human, mouse

技術

immunocytochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... DBN1(1627)

一般說明

The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast

特異性

Cat. # AB10140 detects the internal domain of Drebrin A/E.
May react with human based on sequence homology. Reactivity with other species has not been determined.

免疫原

Epitope: Internal Domain
KLH conjugated synthetic linear peptide.

應用

Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.
Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University.
Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology

品質

Western Blot:
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.

標靶描述

~77 kDa

外觀

Antigen Affinity Purified
Purified rabbit polyclonal antibody in PBS with 0.05% NaN3.

儲存和穩定性

Stable for 1 year at 2-8ºC from date of receipt.

分析報告

Control
Embryonic rat brain (day 16) tissue lysate.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline.
Heather D VanGuilder,Julie A Farley,Han Yan,Colleen A Van Kirk,Matthew Mitschelen et al.
Neurobiology of Disease null
F Ciaffardini et al.
Cell death & disease, 5, e1268-e1268 (2014-05-31)
Cockayne syndrome (CS) is a progressive developmental and neurodegenerative disorder resulting in premature death at childhood and cells derived from CS patients display DNA repair and transcriptional defects. CS is caused by mutations in csa and csb genes, and patients
Kelsie Mozzoni LaBarbera et al.
Journal of neuroscience methods, 358, 109180-109180 (2021-04-10)
Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug discovery of neurodegenerative diseases. This work describes a method for improving scalability through the use

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