8.17073

反丁烯二酸

EMPROVE^® ESSENTIAL, NF, JPE

• 别名: Fumaric acid, trans-1,2-Ethylentricarboxylic acid
• 经验公式（希尔记法）: C₄H₄O₄
• CAS号: 110-17-8
• 分子量: 116.07
• MDL號碼: MFCD00002700
• 分類程式碼代碼: 12352106
• 酶委員會索引編號: 203-743-0

属性

• agency: JPE; NF
• 品質等級: 500
• 蒸汽壓力: <0.001 hPa ( 20 °C)
• 產品線: EMPROVE^® ESSENTIAL
• 形狀: solid
• 自燃溫度: 375 °C
• 效力: 9300 mg/kg LD₅₀, oral (Rat); 20000 mg/kg LD₅₀, skin (Rabbit)
• 技術: API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH值: 2.1 (20 °C, 4.9 g/L in H₂O)
• bp: 290 °C/1013 hPa (sublimed)
• mp: 287 °C
• 轉變溫度: flash point 273 °C
• 溶解度: 4.9 g/L
• 密度: 1.64 g/cm³ at 20 °C
• 應用: liquid formulation; pharmaceutical; solid formulation
• 儲存溫度: 15-25°C
• InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
• InChI 密鑰: VZCYOOQTPOCHFL-OWOJBTEDSA-N

说明

一般說明

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

應用

Fumaric acid is a commonly used ingredient in both food and pharmaceutical applications. In pharmaceutical applications, fumaric acid has been used primarily as a pH modifier.

法律資訊

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 523.4 °F
• 閃點（°C）: 273 °C