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Merck
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主要文件

616454

Sigma-Aldrich

A 83-01

≥97% (HPLC), solid, TGF-β RI kinase inhibitor, Calbiochem

别名:

TGF-β RI 激酶抑制剂 IV

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About This Item

经验公式（希尔记法）:
C25H19N5S
CAS号:
909910-43-6
分子量:
421.52
分類程式碼代碼:
12352200
NACRES:
NA.54

产品名称

TGF-β RI 激酶抑制剂 IV, TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).

品質等級

200

化驗

≥97% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

pale yellow

溶解度

DMSO: 20 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)

InChI 密鑰

HIJMSZGHKQPPJS-UHFFFAOYSA-N

一般說明

一种细胞渗透性三取代吡唑化合物，已显示在表达单个I型TGF-β受体的Mv1Lu R4-2转染子中选择性抑制ALK-4/5/7介导（荧光素酶转录活性测定中IC50分别为45、12和7.5 nM），但不抑制ALK-1/2/3/6介导的细胞信号。在浓度为1 µM的情况下，抑制HaCaT细胞中TGF-β-诱导的Smad2磷酸化和NMuMG细胞中的上皮间质转化。

生化／生理作用

主要靶标
ALK-4/5/7
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：抑制ALK-4/5/7介导的荧光素酶转录活性测定分别为45、12和7.5 nM

包裝

用惰性气体包装

警告

毒性：有害（C）

重構

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。

其他說明

Tojo, M., et al. 2005.Cancer Sci.96, 791.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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