565750

γ-Secretase Inhibitor I

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 别名: γ-Secretase Inhibitor I, Z-LLNle-CHO
• 经验公式（希尔记法）: C₂₆H₄₁N₃O₅
• 分子量: 475.62
• 分類程式碼代碼: 12352200
• NACRES: NA.54

属性

• 品質等級: 200
• 化驗: ≥90% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: DMSO: 10 mg/mL; 50% acetic acid: soluble
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.

Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.

生化／生理作用

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

Z-Leu-Leu-Nle-CHO (Nle = Norleucine)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable