555558

Rho/SRF Pathway Inhibitor, CCG-1423

The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 别名: Rho/SRF Pathway Inhibitor, CCG-1423, N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I
• 经验公式（希尔记法）: C₁₈H₁₃ClF₆N₂O₃
• CAS号: 285986-88-1
• 分子量: 454.75
• MDL號碼: MFCD01566719
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: FC(F)(F)c1cc(cc(c1)C(=O)NOC(C)C(=O)Nc2ccc(cc2)Cl)C(F)(F)F
• InChI: 1S/C18H13ClF6N2O3/c1-9(15(28)26-14-4-2-13(19)3-5-14)30-27-16(29)10-6-11(17(20,21)22)8-12(7-10)18(23,24)25/h2-9H,1H3,(H,26,28)(H,27,29)
• InChI 密鑰: DSMXVSGJIDFLKP-UHFFFAOYSA-N

说明

一般說明

A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα_12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC₅₀ ≤300 nM) and block RhoC/ Gα₁₂-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a K_i of 1.5 µM.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Lundquist, M.R., et al. 2014. Cell156, 563..
Evelyn, C.R., et al. 2007. Mol. Cancer Ther.6, 2249.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable