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52332

Sigma-Aldrich

苯甲基磺酰氟

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

别名:

苯甲基磺酰氟, 苄基磺酰氟，PMSF

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About This Item

经验公式（希尔记法）:
C7H7FO2S
CAS号:
329-98-6
分子量:
174.19
MDL號碼:
MFCD00007424
分類程式碼代碼:
12352202
NACRES:
NA.77

品質等級

200

描述

RTECS - XT8040000

化驗

≥99% (GC)

形狀

crystalline solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated

顏色

white to off-white

溶解度

ethanol: soluble
isopropanol: soluble
methanol: soluble

運輸包裝

ambient

儲存溫度

10-30°C

SMILES 字串

F[S](=O)(=O)Cc1ccccc1

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChI 密鑰

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

一般說明

丝氨酸蛋白酶的不可逆抑制剂。其作用机理类似于氟磷酸二异丙酯。PMSF引起活性位点丝氨酸残基的磺酰化。还报告抑制未成熟胸腺细胞中的核小体间DNA片段化。有关更稳定的相关抑制剂，请参见AEBSF（目录号101500）。

生化／生理作用

主要靶标
丝氨酸蛋白酶
产物不与ATP竞争。
可逆：否
细胞渗透性：否

警告

毒性：腐蚀性（L）

重構

pH 7.5下t½ = 1小时。有效浓度：50 μM。
在复溶后存放于冰箱（4°C）。储备溶液在4°C下可稳定保存至多9个月。

其他說明

Seitz, R., et al. 1993.Int. J. Cancer53, 514.
Weaver, V.M., et al. 1993.Biochem.Cell.Biol.71, 488.
Bourgain, R.H., et al. 1992.Adv.Exp.Med. Biol.316, 427.
Chang, C.T., et al. 1992.Biochem.Int.28, 707.
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法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Skull and crossbonesCorrosion
GHS06,GHS05

訊號詞

Danger

危險聲明

H301,H314

危險分類

Acute Tox. 3 Oral - Skin Corr. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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