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Merck
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Key Documents

487957

Sigma-Aldrich

NOC-18

A nitric oxide (NO) donor similar to NOC-5, NOC-7 and NOC-12 but with an enhanced half-life.

别名:

NOC-18, DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino) bis-ethanamine, DETA NONOate, DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate

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About This Item

经验公式(希尔记法):
C4H13N5O2
分子量:
163.18
分類程式碼代碼:
12352200

品質等級

化驗

≥90% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

顏色

white

溶解度

PBS, pH 7.4: 100 mg/mL
10 mM NaOH: soluble
water: soluble

運輸包裝

ambient

儲存溫度

−20°C

InChI

1S/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h11H,1-6H2/p+2

InChI 密鑰

HMRRJTFDJAVRMR-UHFFFAOYSA-P

一般說明

A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+in vitro. Half-life (t½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).
A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952), and NOC-12 (Cat. No. 487955) but with enhanced half-life for NO release (t½ = 3400 min; PBS, pH 7.4, 22°C). Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+in vitro.

生化/生理作用

Cell permeable: no
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Irritant (B)

重構

Following reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.

其他說明

Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10-13 - German Storage Class 10 to 13


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