420136

JNK Inhibitor IX

The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: JNK Inhibitor IX, N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
• 经验公式（希尔记法）: C₂₀H₁₆N₂OS · xH₂O
• CAS号: 312917-14-9
• 分子量: 332.42 (anhydrous basis)
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: tan
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)
• InChI 密鑰: WQGDQGAFSDMBLA-UHFFFAOYSA-N

说明

一般說明

A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC₅₀ = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC₅₀<5.0). In contrast, SP600125 offers little selectivity between JNK1 and JNK3 (pIC₅₀ = 6.4 and 5.9, respectively) under the same assay conditions.

生化／生理作用

Cell permeable: no

Primary Target
JNK2 and JNK3

Product competes with ATP.

Reversible: no

pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett.17, 1296.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable