356780

Glycyrrhizin, Ammonium Salt

Inhibits replication, adsorption, and penetration of severe acute respiratory syndrome-associated coronavirus (SARS-CV). It is allso a known 11β-hydroxysteroid dehydrogenase type 2 (11-HSD2) inhibitor.

• 别名: Glycyrrhizin, Ammonium Salt, Glycyrrhizic Acid, NH₄ ⁺
• 经验公式（希尔记法）: C₄₂H₆₁O₁₆ · NH₄
• CAS号: 53956-04-0
• 分子量: 839.96
• MDL號碼: MFCD00167400
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white to off-white
• 溶解度: aqueous NH₄OH: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1
• InChI 密鑰: ILRKKHJEINIICQ-OOFFSTKBSA-N

说明

一般說明

A triterpenoid saponin isolated from liquorice roots that displays antiviral and anti-tumor activities. Inhibits replication, adsorption, and penetration of severe acute respiratory syndrome-associated coronavirus (SARS-CV), presumably via its ability to upregulate nitric oxide synthase activity. Reported to block the growth of other viruses, including herpes virus, and helps restore liver functions in patients with hepatitis C. It is allso a known 11β-hydroxysteroid dehydrogenase type 2 (11-HSD2) inhibitor.

A triterpenoid saponin, isolated from liquorice roots, that exhibits anti-viral and anti-tumor activities. Inhibits replication, adsorption, and penetration of severe acute respiratory syndrome-associated coronavirus (SARS-CV), presumably as a result of its ability to upregulate nitric oxide synthase activity. Also reported to hamper the growth of other viruses, including herpes virus. Shown to restore liver function in patients with hepatitis C virus (HCV). Also shown to inhibit 11β-hydroxysteroid dehydrogenase type 2 (11-HSD2).

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Cinatl, J., et al. 2003. Lancet361, 2045.
Tanahashi, T., et al. 2002. J. Steroid Biochem. Mol. Biol.80, 441.
Kondo, Y., and Takano, F. 1994. Biol. Pharm. Bull.17, 759.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable