345752
Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma.
别名:
Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk, Neu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
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About This Item
经验公式（希尔记法）:
C70H123N3O30 · 2NH4
分子量:
1522.80
分類程式碼代碼:
12352211
NACRES:
NA.77
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品質等級
化驗
≥98% (TLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
white
溶解度
water: 1 mg/mL
chloroform/methanol (2:1): soluble
運輸包裝
ambient
儲存溫度
−20°C
一般說明
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
警告
Toxicity: Irritant (B)
其他說明
DeMaria, R., et al. 1997. Science 277, 1652.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Sumeyye Cavdarli et al.
Cells, 10(6) (2021-07-03)
The O-acetylated form of GD2, almost exclusively expressed in cancerous tissues, is considered to be a promising therapeutic target for neuroectoderm-derived tumors, especially for breast cancer. Our recent data have shown that 9-O-acetylated GD2 (9-OAcGD2) is the major O-acetylated ganglioside
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