345733-M

Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk

Contains mainly N-acetylneuraminic acid.

• 别名: Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk, Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
• 经验公式（希尔记法）: C₆₄H₁₁₈N₂O₂₁ · NH₄
• 分子量: 1269.66
• 分類程式碼代碼: 12352211

属性

• 品質等級: 100
• 化驗: ≥98% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white
• 溶解度: chloroform/methanol (2:1): soluble
• 儲存溫度: −20°C

说明

一般說明

Contains mainly N-acetylneuraminic acid. GM₃ and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM₃ is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC₅₀ = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.

Contains mainly N-acetylneuraminic acid. GM₃ and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC₅₀ = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.

M.W. 1198.5 (based on stearoyl - 18:0).

生化／生理作用

Primary Target
Protein kinase C, EGF-receptor tyrosine kinase

Target IC₅₀: 100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions

警告

Toxicity: Irritant (B)

其他說明

Katoh, N. 1995. Life Sci. 56, 157.
Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable