345701

Gambogic Acid, Garcinia hanburyi

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties.

• 别名: Gambogic Acid, Garcinia hanburyi, Guttic Acid, β-Guttiferin
• 经验公式（希尔记法）: C₃₈H₄₄O₈
• CAS号: 2752-65-0
• 分子量: 628.75
• MDL號碼: MFCD16878985
• 分類程式碼代碼: 12352106
• NACRES: NA.77

属性

• 品質等級: 100
• 描述: Merck USA index - 14, 4361
• 化驗: ≥95% (TLC)
• 形狀: amorphous solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: orange
• 溶解度: DMSO: 10 mg/mL; ethanol: soluble
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: O1[C@@]32C4(OC(C3CC(C=C2C(=O)c5c1c(c6c(c5O)C=C[C@](O6)(CCC=C(C)C)C)CC=C(C)C)C4=O)(C)C)C\C=C(\C)/C(=O)O
• InChI: 1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1
• InChI 密鑰: GEZHEQNLKAOMCA-PLUQQRNKSA-N

说明

一般說明

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).

A cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.

生化／生理作用

Cell permeable: yes

MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells

Primary Target
Caspase activator and an apoptosis inducer

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769.
Asano, J., et al. 1996. Phytochemistry41, 815.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H315,H319,H335
• 防範說明: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable