324414

Dynamin Inhibitor V, 34-2

The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

• 别名: Dynamin Inhibitor V, 34-2, 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
• 经验公式（希尔记法）: C₂₅H₃₆N₄O
• CAS号: 1128165-88-7
• 分子量: 408.58
• MDL號碼: MFCD19690957
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 100 mg/mL, clear, yellow
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(NCCCCCCCC)/C(C#N)=C/C1=CN(CCCN(C)C)C2=C1C=CC=C2

说明

一般說明

A cell-permeable, allosteric Dynamin inhibitor (IC₅₀ = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI₅₀ = 4.0–37 µM). It was further shown to be 6-fold more active (IC₅₀ = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC₅₀ = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Chircop, M. et al. 2011. Mol. Cancer Ther.10, 1553.
Hill, T.A., et al. 2009. J. Med. Chem.52, 3762.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable