219419

Cathepsin Inhibitor III

The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 别名: Cathepsin Inhibitor III, Z-FG-NHO-BzOME
• 经验公式（希尔记法）: C₂₇H₂₇N₃O₇
• 分子量: 505.52
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: >90% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated; protect from light
• 顏色: white
• 溶解度: ethanol: 1 mg/mL; DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 10-30°C

说明

一般說明

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1 x 10⁴ M^-1 sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1 sec^-1), cathepsin S (k₂/K_i = 6.6 x 10⁴ M^-1 sec^-1), and papain (k₂/K_i = 1 x 10³ M^-1 sec^-1).

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1.0 x 10⁴ M^-1sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1sec^-1), cathepsin S (k₂/Ki = 6.6 x 10⁴ M^-1sec^-1), and papain (k₂/K_i = 1.0 x 10³ M^-1sec^-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

生化／生理作用

Cell permeable: no

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

k₂/K_i = 1 x 10⁴ M⁻¹ sec⁻¹

警告

Toxicity: Standard Handling (A)

序列

Z-Phe-Gly-NHO-Bz-pOMe

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable