219381
Cathepsin K Inhibitor III
The Cathepsin K Inhibitor III controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Cathepsin K Inhibitor III, Inhibitor I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂
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About This Item
推荐产品
品質等級
化驗
≥97% (HPLC)
形狀
lyophilized solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
顏色
white
溶解度
DMSO: 1 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
一般說明
A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.
A cell-permeable, potent, selective, reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM.
生化/生理作用
Cell permeable: yes
Primary Target
Cathepsin K
Cathepsin K
Product does not compete with ATP.
Reversible: yes
Target Ki: 9.7 nM against cathepsin K
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
H-Phe-Leu-NHNH-CO-NHNH-Leu-Z
外觀
Supplied as a trifluoroacetate salt.
重構
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Wang, D., et al. 2002. Biochemistry41, 8849.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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