203694

bpV(bipy)

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation).

• 别名: bpV(bipy), Potassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
• 线性分子式: K[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (⁵¹V-NMR)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow to orange
• 溶解度: water: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

A potent inhibitor of phosphotyrosine phosphatase activity (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

生化／生理作用

Cell permeable: no

Primary Target
phosphotyrosine phosphatase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 18 nM against PTEN

Target K_i: 100 nM for phosphotyrosine phosphatase

包裝

Packaged under inert gas

警告

Toxicity: Harmful (C)

重構

Unstable in solution; reconstitute just prior to use.

其他說明

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable