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品質等級
化驗
≥90% (TLC)
形狀
solid
反應適用性
reagent type: chelator
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
light yellow
溶解度
DMSO: 10 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChI 密鑰
YJIYWYAMZFVECX-UHFFFAOYSA-N
相关类别
一般說明
BAPTA膜透过形式。可以加载到各种各样的细胞中，在其中它被胞质酯酶水解，并作为活性螯合剂BAPTA捕获在细胞内。防止可卡因引起的心室纤颤。消除维生素D3诱导的细胞内Ca2+增加。诱导蛋白激酶C失活。还抑制毒胡萝卜素诱导的大鼠胸腺细胞凋亡。
BAPTA膜透过形式。可以加载到各种各样的细胞中，在其中它被胞质酯酶水解，并作为活性螯合剂BAPTA捕获在细胞内。防止可卡因引起的心室纤颤。诱导蛋白激酶C失活。还抑制毒胡萝卜素诱导的大鼠胸腺细胞凋亡。
應用
- TRPV1-Dependent Antiproliferative Activity of Dioecious Maclura pomifera Extracts in Estrogen Receptor-Positive Breast Cancer Cell Lines Involves Multiple Apoptotic Pathways.: This study explores how BAPTA/AM, a calcium chelator, contributes to the antiproliferative effects by regulating TRPV1 and apoptotic pathways in breast cancer cells (Rumpa et al., 2024).
- Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence.: The research highlights BAPTA/AM′s role in mitigating mitochondrial calcium overload, which is linked to cellular senescence and aging processes in renal cells (Xiong et al., 2024).
- TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.: This article discusses the role of BAPTA/AM in the modulation of TRPV3 channels, leading to enhanced lipolysis and protection against obesity through the NRF2/FSP1 pathway (Hu et al., 2024).
- Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca(2+) Homeostasis Regulation and Pancreas Autodigestion Inhibition.: BAPTA/AM is utilized to regulate calcium homeostasis, thereby preventing inflammation and autodigestion in acute pancreatitis treatments (Wang et al., 2024).
- IP(3)R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells.: This study investigates how BAPTA/AM inhibits IP3R-mediated calcium release, thereby reducing ferroptotic cell death in neuroblastoma cells (Campos et al., 2024).
包裝
用惰性气体包装
警告
毒性：刺激性（B）
重構
复溶后，分装，用惰性气体吹扫，然后冻存（-20°C）。储备液可在-20°C最长稳定1个月。
其他說明
Bissonnette, M., et al. 1994.Am. J. Physiol.267, G465.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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