推荐产品
生物源
bovine
品質等級
形狀
liquid
儲存期限
2 yr
製造商／商標名
Upstate®
技術
activity assay: suitable
溶解度
water: soluble
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
bovine ... MBP(618684)
一般說明
髓鞘碱性蛋白（MBP）属于固有无序的蛋白质家族。它在大脑和脊髓神经细胞的绝缘层。它是一种存在于中枢神经系统（CNS）中的丰富蛋白质。
Research area: Cell Signaling
MBP is an alkaline protein with a pI of 11.6, constituting approximately 30% of the total protein content of the myelin in the central nervous system.
MBP is an alkaline protein with a pI of 11.6, constituting approximately 30% of the total protein content of the myelin in the central nervous system.
應用
经纯化的MBP（牛髓鞘碱性蛋白）已用于免疫印迹，并在酶联免疫吸附测定（ELISA）中用作标准物。
生化／生理作用
髓鞘碱性蛋白（MBP），也称为髓磷脂执行分子′，有助于中枢神经系统（CNS）髓鞘的形成。多发性硬化症加剧等急性神经障碍以及创伤性脑损伤等患者的脑脊髓液（CSF）中会出现MBP水平升高。此外，在痴呆、脑肿瘤和代谢紊乱等慢性进行性疾病的MBP水平也会升高。
MBP can interact with various polyanionic proteins such as actin, tubulin, Ca2+-calmodulin, and clathrin, as well as negatively charged lipids. Upon binding to these proteins, MBP undergoes structural changes. It is believed to function as a membrane actin-binding protein, potentially enabling its involvement in relaying extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. External signals received by myelin or cultured oligodendrocytes lead to alterations in the phosphorylation of MBP, indicating its participation in signaling. The peptide MBP4-14 is specific for protein kinase C and is resistant to phosphatase activity. Moreover, MBP is extensively utilized in the "in gel" kinase assay, making it a vital biochemical for studying protein kinase activities.
品質
通过成功地磷酸化活性的 MAP 激酶 2/Erk2 进行了常规评估（货号 14-173）
外觀
10mM MOPS，pH 7.0，含 0.05％ 叠氮化钠
儲存和穩定性
在-20°C下可保存2年
其他說明
该产品来自牛源。该产品向某些国家的出口可能受到限制。请联系客户服务或您的当地经销商询问产品的供应和出口选项。
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
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The Journal of biological chemistry, 274(11), 7002-7010 (1999-03-06)
Cytokines trigger the rapid assembly of multimolecular signaling complexes that direct the activation of downstream protein kinase cascades. Two protein kinases that have been linked to growth factor-regulated proliferation and survival are mitogen-activated protein/ERK kinase (MEK) and its downstream target
Discordant activation of stress-activated protein kinases or c-Jun NH2-terminal protein kinases in tissues of heat-stressed mice
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The interaction of fibrinogen (Fg) with intercellular adhesion molecule-1 (ICAM) on B-lymphoid Raji cells results in mitogenesis (Gardiner, E. E., and D'Souza, S. E. (1997) J. Biol. Chem. 272, 15474-15480). Incubation of Raji with Fg resulted in the increased tyrosine
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The Journal of biological chemistry, 276(27), 25302-25308 (2001-04-28)
CEP-1347 (KT7515) promotes neuronal survival at dosages that inhibit activation of the c-Jun amino-terminal kinases (JNKs) in primary embryonic cultures and differentiated PC12 cells after trophic withdrawal and in mice treated with 1-methyl-4-phenyl tetrahydropyridine. In an effort to identify molecular
Ras-independent transformation by v-Src.
Aftab, D T, et al.
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