12-439
视网膜母细胞瘤蛋白（aa 773-928）
Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.
别名:
Rb Protein, Retinoblastoma Protein
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所有图片(1)
About This Item
分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.41
推荐产品
重組細胞
expressed in E. coli
品質等級
形狀
liquid
製造商／商標名
Upstate®
濃度
2.0 mg/mL
技術
activity assay: suitable (kinase)
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
基因資訊
human ... RB1(5925)
品質
常规评估为许多丝氨酸/苏氨酸激酶的底物。
外觀
50 mM Tris-HCl（pH 7.5），150 mM NaCl和500 mM 咪唑
儲存和穩定性
自收到之日起在-20°C可稳定保存1年。 分装保存以避免反复冻融。
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
儲存類別代碼
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Prediction of compounds that are active against a desired biological target is a common step in drug discovery efforts. Virtual screening methods seek some active-enriched fraction of a library for experimental testing. Where data are too scarce to train supervised
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Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood. Of particular interest, phosphorylation of CDK4 at T172 (pT172) is critical
Michael J O'Connor et al.
Oncogene, 40(30), 4872-4883 (2021-06-24)
Cyclin D1 is an essential regulator of the G1-S cell-cycle transition and is overexpressed in many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by many signaling pathways. Here we report that PARP14, a member
Xueqian Gong et al.
Cancer cell, 32(6), 761-776 (2017-12-13)
Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6 inhibitors have shown promising clinical activity in breast cancer and lymphomas, but it is not clear which additional
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