跳转至内容
Merck
所有图片(1)

文件

09-069

Sigma-Aldrich

Anti-ATF6 Antibody

Upstate®, from rabbit

别名:

Anti-ACHM7, Anti-ATF6A

登录查看公司和协议定价
所有图片(1)

About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

100

抗體表格

affinity purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

human

製造商／商標名

Upstate®

技術

western blot: suitable

同型

IgG

NCBI登錄號

NP_031374

UniProt登錄號

P18850

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... ATF6(22926)

一般說明

ATF6 (Activating Transcription Factor 6, Cyclic AMP-dependent transcription factor ATF6) is a stress activated leucine zipper transcription factor involved in activating transcription of endoplasmic reticulum (ER) molecules in response to accumulation of unfolded proteins in the ER. ATF6 is originally a 90 kDa type II transmembrane glycoprotein that is converted to a 50 kDa soluble nuclear form, retaining its N-terminal domain, including the leucine zipper. Unfolded protein accumulation in the ER results in the cleavage of ATF6 to release its cytoplasmic domain that then enters the nucleus. ATF6 binds to an element designated ER Stress Response Element (ERSA) that appears in the promoter of glucose-regulated proteins (GRPs) such as GRP78, GPR94, and calreticulin.

免疫原

KLH-tagged synthestic peptide synthesized to the N-terminal region of human ATF6 designated as the Cytoplasmic Domain.

應用

Detect ATF6 using this Anti-ATF6 Antibody validated for use in WB.
Research Category
Signaling

Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

品質

Routinely evaluated by western blot on HeLa lysate.

標靶描述

90 kDa

外觀

Affinity purified
Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide.

儲存和穩定性

1 year at -20°C

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our 产品选型工具.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Benjamin L Farah et al.
Molecular genetics and metabolism, 122(3), 95-98 (2017-09-11)
GSD Ia (von Gierke Disease, Glycogen Storage Disease Type Ia) is a devastating genetic disorder with long-term sequelae, such as non-alcoholic fatty liver disease and renal failure. Down-regulated autophagy is involved in the development of hepatic metabolic dysfunction in GSD

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门