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特異性
WT1
免疫原
6His标记融合蛋白，对应人WT1（维尔姆斯瘤）的1-181位残基。
應用
抗-WT1抗体（克隆6F-H2）是一种用于检测WT1（又称维尔姆斯瘤）的小鼠单克隆抗体，目前已通过WB、ICC & IHC应用验证。
品質
已通过免疫印迹对Jurkat和Raji细胞的RIPA裂解液进行常规评估
標靶描述
55-60kDa
外觀
形式：纯化
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Toru Sakairi et al.
American journal of physiology. Renal physiology, 298(3), F557-F567 (2009-12-04)
Evidence suggests that loss of podocytes into urine contributes to development of glomerular diseases; shed podocytes are frequently viable and proliferate in culture conditions. To determine the phenotypic characteristics of viable urinary cells derived from human subjects, we established long-term
Embryonic Stem Cells Derived Kidney Organoids as Faithful Models to Target Programmed Nephrogenesis.
Zenglai Tan et al.
Scientific reports, 8(1), 16618-16618 (2018-11-11)
The kidney is a complex organ that is comprised of thousands of nephrons developing through reciprocal inductive interactions between metanephric mesenchyme (MM) and ureteric bud (UB). The MM undergoes mesenchymal to epithelial transition (MET) in response to the signaling from
Toru Sakairi et al.
American journal of physiology. Renal physiology, 299(4), F802-F809 (2010-07-30)
We transformed mouse podocytes by ectopic expression of cyclin-dependent kinase 4 (CDK4). Compared with podocytes transformed with a thermo-sensitive SV40 large T antigen mutant tsA58U19 (tsT podocytes), podocytes transformed with CDK4 (CDK4 podocytes) exhibited significantly higher expression of nephrin mRNA.
Rosalba Parenti et al.
PloS one, 9(12), e114333-e114333 (2014-12-05)
Wilms' tumor gene 1 (WT1) plays complex roles in tumorigenesis, acting as tumor suppressor gene or an oncogene depending on the cellular context. WT1 expression has been variably reported in both benign and malignant peripheral nerve sheath tumors (MPNSTs) by
Aleksandra Rak-Raszewska et al.
Developmental dynamics : an official publication of the American Association of Anatomists (2021-09-09)
Tissue organoids derived from primary cells have high potential for studying organ development and diseases in numerous organs. They recreate the morphological structure and mimic the functions of given organ while being compact in size, easy to produce, and suitable
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