05-644
抗-CAR抗体，克隆RmcB
clone RmcB, Upstate®, from mouse
别名:
46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3 binding protein, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, coxsackie virus B receptor, coxsackie virus and adenovirus receptor
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所有图片(4)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
RmcB, monoclonal
物種活性
human, rat, mouse
製造商／商標名
Upstate®
技術
immunocytochemistry: suitable
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... CXADR(1525)
一般說明
柯萨奇病毒和腺病毒受体（CAR）介导柯萨奇B病毒和许多腺病毒的细胞附着和感染。CAR还介导同型细胞间相互作用。在极化的上皮细胞中，CAR与紧密连接紧密相关，在紧密连接中，CAR有助于溶质和大分子的细胞旁流动。CAR′s的生物学作用尚不明确，但新出现的证据表明它可能在胚胎发育和调节细胞增殖中起作用。
特異性
识别分子量约为6 kDa的CAR。
免疫原
天然人柯萨奇病毒-腺病毒受体蛋白。
應用
免疫细胞化学：
1-2 μg/mL先前批次在HeLa细胞，hCAR转染的CHO细胞中显示出CAR的阳性免疫染色，但在用4%多聚甲醛固定并用0.2%Triton-X透化的未转染的CHO细胞中则没有。
1-2 μg/mL先前批次在HeLa细胞，hCAR转染的CHO细胞中显示出CAR的阳性免疫染色，但在用4%多聚甲醛固定并用0.2%Triton-X透化的未转染的CHO细胞中则没有。
抗CAR抗体，克隆RmcB可检测CAR的水平 & 已出版 & 并经过验证可用于IC & WB。
品質
已通过蛋白质印迹对小鼠小肠裂解液进行了评估。
蛋白质印迹分析：
该抗体的1：500的稀释液在10 µg小鼠小肠裂解液中检测到Car。
蛋白质印迹分析：
该抗体的1：500的稀释液在10 µg小鼠小肠裂解液中检测到Car。
標靶描述
~46 kDa
外觀
形式：纯化
纯化的小鼠单克隆IgG1，溶于含有0.1M Tris甘氨酸（pH 7.4）、0.15M NaCl、0.05％叠氮化钠的缓冲液中。
其他說明
浓度：请参考批次特异性浓缩物的分析证书。
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Klaus Heger et al.
European journal of immunology, 45(6), 1614-1620 (2015-03-20)
Replication-deficient recombinant adenoviruses are potent vectors for the efficient transient expression of exogenous genes in resting immune cells. However, most leukocytes are refractory to efficient adenoviral transduction as they lack expression of the coxsackie/adenovirus receptor (CAR). To circumvent this obstacle
Kenneth J Mandell et al.
Investigative ophthalmology & visual science, 48(9), 3928-3936 (2007-08-29)
Junctional adhesion molecules (JAMs) are a family of adhesion proteins found in intercellular junctions. Evidence suggests that JAM-A is important for the regulation of tight junction assembly and epithelial barrier function. The authors recently reported that JAM-A is expressed in
Anton V Borovjagin et al.
PloS one, 6(10), e24281-e24281 (2011-10-18)
To explore gene therapy strategies for amelogenesis imperfecta (AI), a human ameloblast-like cell population was established from third molars of an AI-affected patient. These cells were characterized by expression of cytokeratin 14, major enamel proteins and alkaline phosphatase staining. Suboptimal
William C Adams et al.
The Journal of general virology, 90(Pt 7), 1600-1610 (2009-03-14)
The coxsackievirus-adenovirus receptor (CAR) is the described primary receptor for adenovirus serotype 5 (Ad5), a common human pathogen that has been exploited as a viral vector for gene therapy and vaccination. This study showed that monocytes and dendritic cells (DCs)
Antitumor effects of bladder cancer-specific adenovirus carrying E1A-androgen receptor in bladder cancer.
Zhai, Z; Wang, Z; Fu, S; Lu, J; Wang, F; Li, R; Zhang, H; Li, S; Hou, Z; Wang, H; Rodriguez, R
Gene Therapy null
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