05-23-3801

Endothelin 3, Human and Rat

Attenuates thrombin-evoked aggregation of human platelets.

• 别名: Endothelin 3, Human and Rat, ET-3, CTCFTYKDKECVYYCHLDIIW
• 经验公式（希尔记法）: C₁₂₁H₁₆₈N₂₆O₃₃S₄
• CAS号: 117399-93-6
• 分子量: 2643.04
• MDL號碼: MFCD00076378
• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated
• 溶解度: 5% acetic acid: 0.5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phopholipase C in fibroblasts expressing ET_A receptors.

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.

生化／生理作用

Cell permeable: no

Primary Target
Stimulator of interleukin-6 production by endothelial cell lines

Product does not compete with ATP.

Reversible: no

包裝

Yes

序列

H-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

外觀

Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.

準備報告

Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他說明

Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun.224, 169.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable