推荐产品
形狀
powder
包裝
pkg of 1 × 25 mg (880670P-25mg)
製造商／商標名
Avanti Research™ - A Croda Brand 880670P
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
O=C(CCC(OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC)=O)OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC.C=C
InChI 密鑰
NVPZJFQMNPKURK-KIAKULPZSA-N
一般說明
Ceramide is one of the products of sphingolipid metabolism. The ceramides differ in their acyl chain length.
應用
C8 PEG750 Ceramide has been used in ceramide liposome formulation to test a method for pH-dependent fusion between liposomes and cellular membranes using a pH low insertion peptide. It is also suitable for use in nanoliposomal formulation.
生化／生理作用
Poly-ethylene glycol (PEG) conjugated to ceramides are applicable as liposomal carriers, enclosing drug molecules. They are known to increase the circulation longevity of the drug due to its neutral surface electrostatic charge. This is inferred to decrease the negative surface charge of the liposomes preventing the release of positively charged encapsulated drug molecule.
包裝
5 mL Amber Glass Screw Cap Vial (880670P-25mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Xin Liu et al.
Blood, 116(20), 4192-4201 (2010-07-31)
The natural killer (NK) type of aggressive large granular lymphocytic (LGL) leukemia is a fatal illness that pursues a rapid clinical course. There are no effective therapies for this illness, and pathogenetic mechanisms remain undefined. Here we report that the
Pavan P Adiseshaiah et al.
Cancer letters, 337(2), 254-265 (2013-05-15)
Autophagy, a catabolic survival pathway, is gaining attention as a potential target in cancer. In human liver and colon cancer cells, treatment with an autophagy inducer, nanoliposomal C6-ceramide, in combination with the autophagy maturation inhibitor, vinblastine, synergistically enhanced apoptotic cell
M S Webb et al.
Biochimica et biophysica acta, 1372(2), 272-282 (1998-07-24)
Poly(ethylene glycol) (PEG) conjugated lipids have been used to increase the circulation longevity of liposomal carriers encapsulating therapeutic compounds. PEG is typically conjugated to distearoylphosphatidylethanolamine (DSPE) via a carbamate linkage that results in a net negative charge on the phosphate
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