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860652P

Avanti

C8 1-磷酸神经酰胺 (d17:1/8:0)

Avanti Research™ - A Croda Brand 860652P, powder

别名:

N-辛酰-神经酰胺-1-磷酸(C17碱)（铵盐）

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About This Item

经验公式（希尔记法）:
C25H53N2O6P
CAS号:
474944-04-2
分子量:
508.67
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

powder

包裝

pkg of 1 × 1 mg (860652P-1mg)

製造商／商標名

Avanti Research™ - A Croda Brand 860652P

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@@]([H])(NC(CCCCCCC)=O)COP([O-])(O)=O.[NH4+]

InChI 密鑰

QZINIJMZYDYICQ-ITEYRTANSA-N

相关类别

一般說明

C8 1-磷酸神经酰胺 (d17:1/8:0)是一种新型的生物活性鞘脂。由神经酰胺激酶（CERK）催化C8-神经酰胺或N-辛酰基-D-赤型-鞘氨醇（C17碱）磷酸化形成。C1P是磷脂酸盐的鞘脂类似物。

生化／生理作用

1-磷酸神经酰胺（C1P）充当促有丝分裂剂。它具有抗凋亡和生存特性。C1P刺激炎症反应并促进吞噬作用。它还具有负调节脂多糖诱导的肿瘤坏死因子-α（TNFα）产生的能力。C1P被认为是激动剂刺激的鞘磷脂代谢的第二个脂质信使。

包裝

5 mL棕色玻璃螺旋盖小瓶（860652P-1mg）

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

历史批次信息供参考:

分析证书(COA)

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Szczepan Józefowski et al.
Journal of immunology (Baltimore, Md. : 1950), 185(11), 6960-6973 (2010-11-03)
LPS is a constituent of cell walls of Gram-negative bacteria that, acting through the CD14/TLR4 receptor complex, causes strong proinflammatory activation of macrophages. In murine peritoneal macrophages and J774 cells, LPS at 1-2 ng/ml induced maximal TNF-α and MIP-2 release
V T Hinkovska-Galcheva et al.
The Journal of biological chemistry, 273(50), 33203-33209 (1998-12-05)
Ceramide, a product of agonist-stimulated sphingomyelinase activation, is known to be generated during the phagocytosis of antibody-coated erythrocytes by polymorphonuclear leukocytes. Agonist-stimulated formation of ceramide-1-phosphate is now shown to occur in 32PO4-labeled neutrophils. Ceramide-1-phosphate is formed by a calcium-dependent ceramide
Antonio Gómez-Muñoz et al.
Journal of lipid research, 45(1), 99-105 (2003-10-03)
It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz, A., P. A. Duffy, A. Martin, L. O'Brien, H-S. Byun, R. Bittman, and D. N. Brindley. 1995. Mol. Pharmacol. 47: 883-889; Gómez-Muñoz, A., L. M. Frago, L. Alvarez
A Gomez-Muñoz et al.
Molecular pharmacology, 47(5), 833-839 (1995-05-01)
Ceramide and ceramide-1-phosphate are sphingolipid analogues of diacylglycerol and phosphatidate, respectively, and they are putative second messengers of agonist-stimulated sphingomyelin metabolism. The interactions of exogenous cell-permeable ceramides and ceramide-1-phosphates in modifying DNA synthesis and signal transduction were investigated in Rat-1

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