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形狀
powder
包裝
pkg of 1 × 10 mg (860506P-10mg)
pkg of 1 × 5 mg (860506P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand
脂質類型
sphingolipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
OC[C@]([H])(NC(CCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+
InChI 密鑰
NPRJSFWNFTXXQC-VHEBQXMUSA-N
一般說明
C6神经酰胺（d18:1/6:0）是一种具有细胞通透性的短链神经酰胺。它包含通过酰胺键与脂肪酰基链相连的氨基醇链。
應用
C6神经酰胺（d18:1/6:0）已被作为化疗药物用于测试其在乳腺癌细胞和卵巢癌细胞系中的抗肿瘤作用。它还被用于测试癌细胞中的化疗增敏作用。
生化／生理作用
C6神经酰胺（d18:1/6:0）可参与到增殖抑制和细胞凋亡诱导。当与酸性神经酰胺酶抑制剂DM102，即[(2R,3Z)-N-(1-羟基十八烷基-3-en-2-基）新戊酰酰胺]结合使用时，可有助于人乳腺癌细胞系的细胞死亡。C6神经酰胺可作为化疗的一种辅助手段。它可通过AKT（丝氨酸/苏氨酸特异性蛋白激酶）去磷酸化和α-微管蛋白乙酰化引发抗肿瘤作用。
包裝
5 mL琥珀色玻璃螺旋盖小瓶（860506P-10mg）
5 mL琥珀色玻璃螺旋盖小瓶（860506P-5mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
也與該產品經常一起購買
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth
Flowers M, et al.
Breast Cancer Research and Treatment, 133(2), 447-458 (2012)
Q-y Zhu et al.
Cell death & disease, 2, e117-e117 (2011-03-04)
Histone deacetylase inhibitors (HDACIs) have shown promising anti-tumor effects for a variety of malignancies, however, many tumors are reportedly resistant to them. In this study, we made a novel discovery that co-administration of HDACIs (Trichostatin A (TSA) and others) and
C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: a mechanism study
Yang L, et al.
Experimental Cell Research, 332(1), 47-59 (2015)
Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition
Ji C, et al.
Oncogene, 29(50), 6557-6557 (2010)
C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and alpha-tubulin hyperacetylation both in vitro and in vivo
Zhu QY, et al.
Cell Death & Disease, 2(1), e117-e117 (2011)
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