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Merck

857235P

Avanti

(2S)-OMPT

Avanti Research - A Croda Brand

别名:

(2S)-1-(9Z-十八烯酰基)-2-O-甲基-甘油-3-硫代磷酸酯(铵盐)

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About This Item

经验公式(希尔记法):
C22H46NO6PS
分子量:
483.64
分類程式碼代碼:
51191904

化驗

≥99% (TLC)

形狀

powder

包裝

pkg of 1 × 25 mg (857235P-25MG)
pkg of 1 × 5 mg (857235P-5MG)

製造商/商標名

Avanti Research - A Croda Brand

脂質類型

phospholipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[NH4+].CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)([O-])=S)OC

應用

lipids research

包裝

5 mL Amber Glass Screw Cap Vial (857235P-5MG);5 mL Amber Glass Screw Cap Vial (857235P-25MG)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

49.5 °F - closed cup

閃點(°C)

9.7 °C - closed cup


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Lian Qian et al.
Journal of medicinal chemistry, 46(26), 5575-5578 (2003-12-12)
The metabolically stabilized LPA analogue, 1-oleoyl-2-O-methyl-rac-glycerophosphothioate (OMPT), is a potent agonist for the LPA(3) G-protein-coupled receptor. A new enantiospecific synthesis of both (2R)-OMPT and (2S)-OMPT is described. Calcium release assays in both LPA(3)-transfected insect Sf9 and rat hepatoma Rh7777 cells
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
Hasegawa Y, et al.
The Journal of Biological Chemistry, 278, 11962-11969 (2003)
Yutaka Hasegawa et al.
The Journal of biological chemistry, 278(14), 11962-11969 (2003-01-30)
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that acts through G protein-coupled receptors. Most cell lines in culture express one or more LPA receptors, making it difficult to assign a response to specific LPA receptors. Dissection of the signaling
Pericytes prevent regression of endothelial cell tubes by accelerating metabolism of lysophosphatidic acid
Motiejunaite R, et al.
Microvascular Research, 93(2), 62-71 (2014)
Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Qian L, et al.
Journal of Medicinal Chemistry, 46, 5575-5578 (2003)

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