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描述
1-oleoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
化驗
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
形狀
powder
包裝
pkg of 1 × 1 g (857130P-1g)
pkg of 2 × 100 mg (857130P-200mg)
pkg of 1 × 25 mg (857130P-25mg)
製造商／商標名
Avanti Polar Lipids
脂質類型
cardiolipins
phospholipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
O[C@](COP([O-])(O)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
InChI
1S/C21H41O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);/q;+1/p-1/b10-9-;/t20-;/m1./s1
InChI 密鑰
XGRLSUFHELJJAB-JGSYTFBMSA-M
一般說明
溶血磷脂酸（LPA）属于磷脂类，其甘油主链由磷酸基、脂肪链和羟基连接而成。磷酸基连接sn-3位置，脂肪链连接sn-1 或sn-2位置。羧基连接剩余的sn-1 或sn-2位置。
應用
18:1 Lyso PA 或1-油酰基-2-羟基-sn-甘油-3-磷酸盐已被用于：研究其对嗜铬细胞瘤细胞12 (PC12) 和原发性星形胶质细胞中的瞬时胞内钙浓度[Ca2+的影响。它还被用于研究其对禁食的小鼠中血糖水平和身体耐力的影响。
生化／生理作用
对LPA的生物反应：细胞增生、抑制分化（成神经细胞瘤细胞、成肌细胞）、血小板聚集、平滑肌收缩、神经递质释放、应力纤维形成/细胞变圆/神经突起退缩、细胞表面纤维连接蛋白结合、肿瘤细胞侵袭、趋化作用（盘基网柄菌变形虫）、Cl介导的膜去极化（成纤维细胞）、基于连接蛋白43的细胞间通信的抑制、增加的紧密连接渗透性（脑内皮细胞）注意：LPA的生物活性似乎需要长的（即C16至C18）酰基碳链，这种碳链通常与膜脂质有关，尽管对单一类型酰基碳链的最适宜要求不是普遍性的。生物活性随碳链变短而下降。在血清中，含有LPA 的油酰基和棕榈酰脂肪酸是主要类型。
包裝
5 mL 透明玻璃密封安瓿（857130P-200mg）
5 mL 透明玻璃密封安瓿（857130P-25mg）
60 mL 琥珀色宽口螺帽玻璃瓶(857130P-1g)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Ethan Sagher et al.
Cancer cell international, 14, 75-75 (2014-10-18)
The small molecule NSC676914A was previously identified as an NF-κB inhibitor in TPA-stimulated HEK293 cells (Mol Can Ther 8:571-581, 2009). We hypothesized that this effect would also be seen in ovarian cancer cells, and serve as its mechanism of cytotoxicity.
Susumu Antoku et al.
Developmental cell, 51(5), 602-616 (2019-12-04)
Mutations in the lamin A/C gene (LMNA) cause cardiomyopathy and also disrupt nuclear positioning in fibroblasts. LMNA mutations causing cardiomyopathy elevate ERK1/2 activity in the heart, and inhibition of the ERK1/2 kinase activity ameliorates pathology, but the downstream effectors remain
Byung-Hwan Lee et al.
Neuroscience letters, 612, 256-260 (2015-12-27)
Ginseng has a long history of use as a tonic for restoration of vigor. One example of ginseng-derived tonic effect is that it can improve physical stamina under conditions of stress. However, the active ingredient and the underlying molecular mechanism
Vishal Kumar Gupta et al.
Apoptosis : an international journal on programmed cell death, 25(1-2), 135-150 (2019-12-24)
Lysophosphatidic acid (LPA) is a bioactive lipid, which plays an indispensable role in various physiological and pathological processes. Moreover, an elevated level of LPA has been observed in malignancies of different origins and implicated in their progression via modulation of
Yunzhou Dong et al.
Mediators of inflammation, 2017, 2754756-2754756 (2017-03-30)
Lysophosphatidic acid (LPA), a naturally occurring bioactive phospholipid, activates G protein-coupled receptors (GPCRs), leading to regulation of diverse cellular events including cell survival and apoptosis. Despite extensive studies of the signaling pathways that mediate LPA-regulated cell growth and survival, the
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