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描述
1-stearoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
化驗
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
形狀
powder
包裝
pkg of 1 × 25 mg (857128P-25mg)
製造商／商標名
Avanti Research™ - A Croda Brand
脂質類型
cardiolipins
phospholipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O.[Na+]
一般說明
溶血磷脂酸（1-或2-酰基溶血磷脂酸/LPA）是一种生物活性磷脂，血浆水平较低（~100 nM）。它通常在细胞膜磷脂合成过程中形成。它由多种细胞产生，如活化血小板、上皮细胞、白细胞、神经细胞和肿瘤细胞。18:0 Lyso PA在sn-1位有硬脂酸，在sn-2位有羟基。
應用
18:0 Lyso PA适用于：
- 色谱法测定LPA中性pH和酸性pH条件下的提取回收率
- 用作内标，研究肠源性溶血磷脂酸在血脂异常和动脉粥样硬化中的作用
- 研究其对网格蛋白依赖性内吞作用的影响
生化／生理作用
溶血磷脂酸（1-或2-酰基溶血磷脂酸/LPA）可通过G蛋白偶联受体（GPCR）调节细胞运动、增殖、侵袭、存活和生长因子的产生。
包裝
5 mL棕色玻璃螺旋盖样品瓶（857128P-25mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation, 2017 (2017)
Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
Ailte I, et al.
Traffic, 18(3), 176-191 (2017)
Mohamad Navab et al.
Journal of lipid research, 54(12), 3403-3418 (2013-10-03)
We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic atherosclerosis in LDL receptor-null (LDLR⁻/⁻) mice fed a Western diet (WD). Here we demonstrate that WD increases unsaturated (but
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column
Shan L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864(1-2), 22-28 (2008)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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