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描述
n-dodecylphosphocholine
化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 g (850336P-1g)
pkg of 1 × 25 g (850336P-25g)
pkg of 1 × 5 g (850336P-5g)
製造商／商標名
Avanti Research™ - A Croda Brand
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[P](=O)([O-])(OCC[N+](C)(C)C)OCCCCCCCCCCCC
InChI
1S/C17H38NO4P/c1-5-6-7-8-9-10-11-12-13-14-16-21-23(19,20)22-17-15-18(2,3)4/h5-17H2,1-4H3
InChI 密鑰
QBHFVMDLPTZDOI-UHFFFAOYSA-N
一般說明
MAPCHO™-12 或正十二烷基磷酸胆碱是短链去污剂。
十二烷基磷酸胆碱是月桂酰溶血磷脂酰胆碱的结构类似物，其对水解降解更稳定。该脂质通常用作膜蛋白溶解和纯化的去污剂。研究表明十二烷基磷酸胆碱可通过调节紧密连接来改善亲水性化合物的细胞旁通透性。这可能对其用于口服或鼻腔给药有影响。
應用
MAPCHO™-12 适合用作核磁共振实验中枯草芽孢杆菌细胞色素 b558 蛋白的去污剂 。它也适用于gp41（gp41CT）蛋白的细胞质尾的纯化和胶束制备。
生化／生理作用
MAPCHO-12™ 或正十二烷基磷酸胆碱与 1,2-二肉豆蔻酰基-sn-甘油-3-磷酸胆碱（DMPC）结合可用于膜模拟 bicelle 系统，用于基于方向的膜蛋白研究。它在膜胶束结构中提供了两性离子表面。
包裝
125 mL 带螺旋盖的琥珀色宽口玻璃瓶（850336P-5g）
20 mL 透明玻璃螺旋盖小瓶（850336P-1g）
250 mL 带螺旋盖的琥珀色宽口玻璃瓶（850336P-25g）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
N P Santisteban et al.
Biochimica et biophysica acta. Biomembranes, 1862(5), 183199-183199 (2020-01-29)
The lipid bilayer disrupting effect of antimicrobial peptides (AMPs) has been widely studied in model-lipid systems by applying biophysical techniques such as 2H NMR spectroscopy. Real bacteria cell envelopes contain non-lipid components, such as peptidoglycan, and thus it is important
Nina Liu et al.
Heliyon, 5(12), e03018-e03018 (2020-01-01)
Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined "class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the fusion subunit (e.g., GP2 for
Solution structure and membrane interaction of the cytoplasmic tail of HIV-1 gp41 protein
Murphy RE, et al.
Structure, 25(11), 1708-1718 (2017)
Thermodynamics, size, and dynamics of zwitterionic dodecylphosphocholine and anionic sodium dodecyl sulfate mixed micelles
Sikorska E, et al.
Journal of Thermal Analysis and Calorimetry, 123(1), 511-523 (2016)
Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Nolandt OV, et al.
Biochimica et Biophysica Acta - Biomembranes, 1818(5), 1142-1147 (2012)
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