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化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 g (791056P-1g)
製造商／商標名
Avanti Research™ - A Croda Brand 791056P
脂質類型
neutral lipids
neutral glycerides
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
2-hydroxyoleic acid (2-OHOA) is a synthetic and non-β oxidation-metabolizable oleic acid derivative. It contains 18 carbon atoms in its fatty acid chain length.
應用
2-hydroxyoleic acid (2-OHOA) is suitable for use:
- to study its antihypertensive action in adult spontaneously hypertensive rats (SHRs)
- to study the chemical structure-effect relation of 2-OHOA in the reduction of body weight in rats
- as an antitumor compound, to study its effect on xenografts lipidome based on imaging mass spectrometry (IMS)
生化／生理作用
2-Hydroxy Oleic Acid is an inducer of cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2-Hydroxy Oleic Acid increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.
2-hydroxyoleic acid (2-OHOA) acts as a potential antihypertensive agent. Oral administration of 2-OHOA is used to reduce body weight.
包裝
20 mL Clear Glass Screw Cap Vial (791056P-1g)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
2-Hydroxyoleic acid: a new hypotensive molecule
Alemany R, et al.
Hypertension, 43(2), 249-254 (2004)
Silvia Terés et al.
Autophagy, 8(10), 1542-1544 (2012-08-16)
The very high mortality rate of gliomas reflects the unmet therapeutic need associated with this type of brain tumor. We have discovered that the plasma membrane fulfills a critical role in the propagation of tumorigenic signals, whereby changes in membrane
Optimized protocol to analyze changes in the lipidome of xenografts after treatment with 2-hydroxyoleic acid
Ferna?ndez R, et al.
Analytical Chemistry, 88(1), 1022-1029 (2015)
Stefano Piotto et al.
Biochimica et biophysica acta, 1838(6), 1628-1637 (2014-01-15)
The complex dual mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent anti-tumor compound used in membrane lipid therapy (MLT), has yet to be fully elucidated. It has been demonstrated that 2OHOA increases the sphingomyelin (SM) cell content via SM
Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase
Alemany R
Journal of Lipid Research, 47(8), 1762-1770 (2006)
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