700039P

24(S),25-epoxycholesterol

Avanti Research^™ - A Croda Brand

• 别名: (24S,25)-Epoxycholesterol, (3β,24S)-24,25-Epoxycholest-5-en-3-ol
• 经验公式（希尔记法）: C₂₇H₄₄O₂
• CAS号: 77058-74-3
• 分子量: 400.64
• MDL號碼: MFCD03695562
• 分類程式碼代碼: 12352211
• NACRES: NA.25

属性

• 形狀: powder
• 包裝: pkg of 1 × 1 mg (700039P-1mg); pkg of 1 × 5 mg (700039P-5mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: O1[C@H](C1(C)C)CC[C@H]([C@@H]2[C@@]3([C@H]([C@H]4[C@@H]([C@]5(CC[C@@H](CC5=CC4)O)C)CC3)CC2)C)C
• InChI: 1S/C27H44O2/c1-17(6-11-24-25(2,3)29-24)21-9-10-22-20-8-7-18-16-19(28)12-14-26(18,4)23(20)13-15-27(21,22)5/h7,17,19-24,28H,6,8-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,24+,26+,27-/m1/s1
• InChI 密鑰: OSENKJZWYQXHBN-XVYZBDJZSA-N

说明

一般說明

24(S),25-epoxycholesterol is an oxysterol, which is produced by fibroblasts, macrophages and brain cells.

24(S),25-epoxycholesterol is a cholesterol-derived oxysterol, which is produced by fibroblasts, macrophages, and the brain cells. 24(S),25-epoxycholesterol is synthesized de novo in the mevalonate pathway.

應用

24(S),25-epoxycholesterol has been used as an oxysterol/internalstandard to study the effects of AY9944-induced changes in neurospheres.

生化／生理作用

Exogenous addition of 24(S),25-epoxycholesterol lowers 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase activity, represses sterol regulatory element-binding protein (SREBP) processing, and induces liver × receptor (LXR) -gene targets in vitro.

包裝

5 mL Amber Glass Screw Cap Vial (700039P-1mg)

5 mL Amber Glass Screw Cap Vial (700039P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全信息

• 儲存類別代碼: 11 - Combustible Solids