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形狀
powder
包裝
pkg of 1 × 100 mg (141101P-100mg)
pkg of 5 × 100 mg (141101P-500mg)
製造商／商標名
Avanti Research™ - A Croda Brand
脂質類型
lipid extracts
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
脑极性脂质提取物是通过丙酮沉淀后再用乙醚提取丙酮不溶物而提取自总脂质提取物的。
脑极性脂质提取物的主要脂质组分为磷脂酰乙醇胺。它还含有磷脂酰丝氨酸和磷脂胆酰碱。所含微量组分包括磷脂酸和磷脂酰肌醇。
應用
脑极性脂质提取物用于平行人工膜渗透模型 (PAMPA) 的膜制备，以评估血脑屏障渗透性和研究药物渗透性。
生化／生理作用
来自脑、肝、肾等哺乳动物组织的脂质提取物可用于建立膜模型，模拟天然生物膜。脑脂质（尤其是极性组分）在对朊病毒种子的淀粉样蛋白形成的抑制中起重要作用。
包裝
5 mL透明玻璃密封安瓿（141101P-100mg）
5 mL透明玻璃密封安瓿（141101P-500mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs
Hallifax D, et al.
European Journal of Pharmaceutical Sciences, 45(5), 570-574 (2012)
Rapid screening of brain-penetrable antioxidants from natural products by blood-brain barrier specific permeability assay combined with DPPH recognition
Zhu J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 151, 42-48 (2018)
Estefanía de Munck et al.
PloS one, 11(9), e0162723-e0162723 (2016-09-16)
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal
David S Wexler et al.
Journal of biomolecular screening, 10(4), 383-390 (2005-06-21)
Solubility and permeability are intimately linked in drug absorption processes. They have, however, been traditionally assayed separately. To support this linkage, a combined solubility/permeability assay was developed for determining absorption properties of chemical entities. First, solubility is determined at 4
Endogenous brain lipids inhibit prion amyloid formation in vitro
Hoover CE, et al.
Journal of Virology, 91(9), e02162-e02116 (2017)
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