936626

Fmoc-Val-Cit-PAB-PNP

≥95%

• 别名: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-L-ornithinamide (ACI), L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- (9CI, ACI)
• 经验公式（希尔记法）: C₄₀H₄₂N₆O₁₀
• CAS号: 863971-53-3
• 分子量: 766.80
• MDL號碼: MFCD22200278
• 分類程式碼代碼: 12352209

属性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder or crystals
• 顏色: Off White to Yellow to Beige
• 儲存溫度: 2-8°C
• SMILES 字串: C(OC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(OC2=CC=C(N(=O)=O)C=C2)=O)C=C1 )=O)CCCNC(N)=0)=O)C(C)C)=O)C3C=4C(C=5C3-CC-CC5)=CC-CC4
• InChI: 1S/C40H42N6O10/c1-24(2)35(45-39(50)54-23-33-31-10-5-3-8-29(31)30-9-4-6-11-32(30)33)37(48)44-34(12-7-21-42-38(41)49)36(47)43-26-15-13-25(14-16-26)22-55-40(51)56-28-19-17-27(18-20-28)46(52)53/h3-6,8-11,13-20,24,33-35H,7,12,21-23H2,1-2H3,(H,43,47)(H,44,48)(H,45,50)(H3,41,42,49)/t34-,35-/m0/s1
• InChI 密鑰: USMYACISHVPTHK-PXLJZGITSA-N

说明

應用

This is a cathepsin cleavable linker used in bioconjugation, specifically in the construction of antibody drug conjugates (ADC & Bioconjugation).

特點和優勢

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers.

其他說明

ADC & Bioconjugation.

Chemical Biology Tools.

http://pubs.rsc.org/en/Content/ArticleLanding/2011/MB/C0MB00074D#!divAbstract