936499

3-Pyridinecarboxylic acid, 6-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-

≥95%

• 别名: 6-[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-3-pyridinecarboxylic acid
• 经验公式（希尔记法）: C₂₃H₂₁N₅O₆
• CAS号: 2633591-27-0
• 分子量: 463.44
• 分類程式碼代碼: 12352106
• NACRES: NA.22

属性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder or crystals
• 顏色: light yellow to dark yellow
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(O)C1=CN=C(C=C1)N2CCN(C3=CC=C4C(=O)N(C(=O)C4=C3)C5C(=O)NC(=O)CC5)CC2

说明

應用

This is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

其他說明

1. Targeted Protein Degradation by Small Molecules
2. Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
3. Small-Molecule PROTACS: New Approaches to Protein Degradation
4. Targeted Protein Degradation: from Chemical Biology to Drug Discovery
5. Impact of linker length on the activity of PROTACs

法律資訊

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable