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一般說明
Poly(oligo(ethylene glycol) methacrylate) (POEGMA) is a family of polymers consisting of a hydrophobic methacrylate backbone and hydrophilic ethylene oxide (EO) side groups with highly branched architecture. The highly branched architecture with a high density of oligo EO moities enhances the solubility of the polymer in water.
應用
- Drug delivery- enhances the stability and delivery of siRNA and eliminates PEG antigenicity
- Biosensor coatings- provides an anti-fouling surface
- Stimuli-responsive hydrogels for tissue engineering, drug delivery, and other biomedical applications
Poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) is a family of polymers consisting of a hydrophobic methacrylate backbone and hydrophilic ethylene oxide (EO) side groups with highly branched architecture . The side chain EO segments enhance the solubility of the polymer in water , exhibiting many interesting properties such as non-fouling , stealth, anti-PEG antibodies & thermo-responsive behaviors.
特點和優勢
- Highly branched architecture and high density of oligo ethylene oxide moieties
- Water soluble
- Nonfouling and thermo-responsive behaviors
- Viable alternative to PEG in biological and biomaterial applications
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays
Heggestad J., et al.
Advanced Materials, 32 (2020)
Rafael Pires-Oliveira et al.
Langmuir : the ACS journal of surfaces and colloids, 36(49), 15018-15029 (2020-12-05)
Understanding of the temperature-induced phase transition of poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) random copolymers with varied composition remains largely incomplete. Upon heating they can form either macroscopically phase-separated aggregates or micelles. We examined the effect of polymer architecture by
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