929867

Linear polyethylenimine-block-poly(ethylene glycol)

PEG average M_n 2,000, PEI average M_n 30,000

• 别名: PEG-b-PEI, PEG-PEI, Poly(ethylene glycol)-block-polyethylenimine
• 线性分子式: CH₃(C₂H₄O)_n(C₂H₅N)_mOH
• 分類程式碼代碼: 12162002
• NACRES: NA.25

属性

• 形狀: powder or solid
• 品質等級: 100
• 分子量: PEG M_n 2000 Da; PEG average M_n 2,000; PEI M_n 30000 Da; PEI average M_n 30,000
• 顏色: white to pale yellow
• 儲存溫度: 2-8°C

说明

一般說明

Linear polyethylenimine-block-poly(ethylene glycol) (PEG-b-PEI) is a block copolymer of cationic poly(ethylene imine) (PEI) and hydrophilic poly(ethylene glycol) (PEG). PEI is one of the most commonly used cationic polymers for gene delivery applications and PEG improves nucleic acid delivery by producing a stealth barrier.

應用

Due to their low immunogenicity profiles, polymeric non-viral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy.

特點和優勢

Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable