925225

KB02yne

• 别名: 2-Chloro-1-(6-(hex-5-yn-1-yloxy)-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one, Functionalized scout fragment
• 经验公式（希尔记法）: C₁₇H₂₀ClNO₂
• CAS号: 2376152-06-4
• 分子量: 305.80
• MDL號碼: MFCD00003568
• 分類程式碼代碼: 12352101
• NACRES: NA.22

属性

• 形狀: powder or crystals (or Solid or Liquid)
• 品質等級: 100
• 反應適用性: reagent type: chemical modification reagent; reaction type: click chemistry
• 儲存溫度: 2-8°C

说明

應用

KB02yne is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131).

Related useful products may include:

• Cysteine-reactive fragments: KB02 (912131), KB03 (912654), KB05 (911798), sulfoxide (925136), CoLDR probe (923818)
• Functionalized scout fragments: KB02-COOH (925047), KB05yne (925144)
• Electrophilc degraders featuring scout fragments: KB02-SLF (914738), KB03-SLF (914975), KB05-SLF (913715), Biotin-SLF (914223)
• Cysteine-reactive probes for chemoproteomics: IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059)

Technology spotlight: Proteomic Ligandability Assessment

其他說明

Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization

The Proteome-Wide Potential for Reversible Covalency at Cysteine

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3