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914746

Sigma-Aldrich

Thiophosphoro alkyne dichloridate

≥95%

别名:

O-(Prop-2-yn-1-yl) phosphorodichloridothioate, Chemoselective histidine labeling reagent, Phosphorodichloridothioate 2-propyn-1-ol, Propargyl thiophosphorodichloridate, TPAC, Thiophosphoro alkyne dichloridate, Thiophosphorodichloridate reagent, Thiophosphorus electrophile

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About This Item

经验公式（希尔记法）:
C3H3Cl2OPS
CAS号:
21300-59-4
分子量:
189.00
分類程式碼代碼:
12352200

品質等級

100

化驗

≥95%

形狀

liquid

儲存溫度

−20°C

應用

Thiophosphoro alkyne dichloridate (TPAC) is a histidine labeling reagent developed by the Chang lab that mimics native post-translational His phosphorylation. The alkyne allows for subsequent reactions or addition of payloads by copper-assisted alkyne-azide cycloaddition (CuAAC) chemistry. TPAC was also demonstrated to covalently modify His-tags, and by clicking on polyarginine tags, enabled protein delivery into live cells.

其他說明

Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation

儲存類別代碼

10 - Combustible liquids

閃點（°F）

175.8 °F

閃點（°C）

79.9 °C

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Shang Jia et al.
Journal of the American Chemical Society, 141(18), 7294-7301 (2019-04-25)
Site-selective bioconjugation to native protein residues is a powerful tool for protein functionalization, with cysteine and lysine side chains being the most common points for attachment owing to their high nucleophilicity. We now report a strategy for histidine modification using

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